Chapter 11 : DNA Replication
Outline: * Semiconservative Replication o Meselson-Stahl Experiment * DNA polymerases and DNA elongation * Molecular model of DNA replication o Initiation of Replication o Semidiscontinuous DNA replication o Rolling circle replication * Replication of telomeres in eukaryotes DNA replication underlies the process of inheritance at all levels (cellular, organismal, population). DNA replication occurs as prelude to cell division ( S phase of cell cycle in eukaryotes). DNA in all organisms is the end point in a continuous series of replications going back to the origin of life, almost 4 billion yrs ago. DNA replication is based on complementarity of DNA molecules and on ability of proteins to form specific interactions with specific sequences of DNA. Semiconservative Replication
* Watson and Crick model of DNA suggested that each strand could serve as template for synthesis of new strand. Their model is called semiconservative DNA replication * Two other models based on template-based synthesis were also...