Molecular Modeling of Nucleic Acids

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Mã tài liệu: 200912

Số trang: 450

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"The editors brought together as wide a range of approaches to nucleic acid modeling as possible. The book is about more than just molecular modeling in the computational chemistry sense. As the editors explain in their introduction, the conception of the original DNA double helix by Watson and Crick was a molecular modeling exercise, i.e., using available experimental information to construct a three-dimensional structure. Not all modeling need be done on a computer. . . . The book is organized into sections covering basic computational issues, crystallography, spectroscopy, secondary structure prediction, molecular dynamics simulations, and modeling with low-resolution data. . . . The book is a rich source of information about DNA and RNA and will help the reader appreciate the wide panorama of experimental and computational research directions. This volume should be in complete collections of books on computational chemistry or nucleic acids."--Journal of Medicinal Chemistry
"Proceedings of the April 1997 symposium. An overview and 25 contributions emphasize the same synergistic interplay of theoretical molecular modeling approaches and experimental structure determination methods that were decisive in the success of Watson and Crick in defining the double helix. Other themes include the urgency of dealing with the problem of conformational flexibility and heterogeneity in nucleic acids, particularly for NMR structure determination; the value of treating electrostatic interactions as accurately as possible; the need to consider kinetic factors in modeling the final folded conformations of large structures; and the value of a hierarchical approach to three-dimensional structure."--SciTech Book News
Product Description
Covering numerous topics in modeling nucleic acids, this volume looks at the role of various spectroscopic methods, simulations of molecular dynamics using particle mesh methods, and dynamic and genetic algorithms for predicting RNA secondary structure. It also covers the thermodynamics of nucleic acid folding and three-dimensional structure prediction based on sequence information.
Product Details
Hardcover: 450 pages
Publisher: An American Chemical Society Publication; illustrated edition edition (December 1, 1997)
Language: English
ISBN-10: 0841235414
ISBN-13: 978-0841235410
Product Dimensions: 9.1 x 6.1 x 1.1 inches

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