This best-selling resource utilizes a comprehensive yet practical approach that students understand. The authors present facts and pathways to emphasize how the underlying biochemistry is related to the body's overall physiological functions. Detailed case studies show students the relationship between biochemistry and clinical problems. The Second Edition has been heavily revised with completely updated illustrations while maintaining the unique, patient-oriented approach that made the original so popular. A new CD-ROM in the back of the book features chapter-by-chapter test questions, detailed 3-D representations of enzyme structure, PowerPoint slides, and real patient stories..