In recent years of 21st century, development of technology has extended to a process oriented, e-business world that is increasing in business-to-business, web-centric interactions. Being regarded as a new approach that emerging in today’s global economics, cross-border teamwork becomes more and more popular in enhancing competitive advantages. This paper examines the concepts of teamwork, cross-border teamwork and virtual teamwork. It presents a framework to deal with cross-border teamwork approach and to build up an effective cross-border team.